Advanced Quantitative Fluorescence Microscopy to Probe the Molecular Dynamics of Viral Entry, Science Lab

Viral entry into the host cell requires the coordination of many cellular and viral proteins in a precise order. Modern microscopy techniques are now allowing researchers to investigate these interactions with higher spatiotemporal resolution than ever before. Here we present two examples from the field of HIV research that make use of an innovative quantitative imaging approach as well as cutting edge fluorescence lifetime-based confocal microscopy methods to gain novel insights into how HIV fuses to cell membranes and enters the cell.

Virus Entry - an overview

NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein

Quantum Dots: A Promising Fluorescent Label for Probing Virus Trafficking

Biomolecular condensates modulate membrane lipid packing and hydration

Advanced quantitative fluorescence microscopy to probe the molecular dynamics of viral entry

IJMS, Free Full-Text

Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics - Laboratory Investigation

Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association

Frontiers Evolution, Interspecies Transmission, and Zoonotic Significance of Animal Coronaviruses

Advanced Quantitative Fluorescence Microscopy to Probe the Molecular Dynamics of Viral Entry, Science Lab