The Safety of High Dose Labetalol in the Pregnant Population

Hypertension in pregnancy is one of the leading causes of maternal mortality and rapid treatment is critical. Treatment of emergent hypertensive crises in pregnancy is limited to only three medications, one of which is labetalol. Current literature recommends a daily maximum intravenous labetalol dose of 300 mg per day. However, this maximum dose has not been studied in pregnancy where higher doses may be required.

Oral nifedipine vs. intravenous labetalol for treatment of pregnancy‐induced severe pre‐eclampsia - Shi - 2016 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

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The Safety of High Dose Labetalol in the Pregnant Population

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Comparing the efficacy of oral labetalol with oral amlodipine in achieving blood pressure control in women with postpartum hypertension: randomized controlled trial (HIPPO study—Hypertension In Pregnancy & Postpartum Oral-antihypertensive therapy

What is the evidence for using labetalol as a first-line treatment option for hypertension in pregnancy?

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The Safety of High Dose Labetalol in the Pregnant Population

Frontiers Pharmacokinetic data in pregnancy: A review of available literature data and important considerations in collecting clinical data